Oncogenic activation of androgen receptor

Cooperation between Polycomb and androgen receptor during oncogenic transformation.

Androgen receptor (AR) is a hormone-activated transcription factor that plays important roles in prostate development and function, as well as malignant transformation. The downstream pathways of AR, however, are incompletely understood. AR has been primarily known as a transcriptional activator inducing prostate-specific gene expression. Through integrative analysis of genome-wide AR occupancy...

TITLE : Inhibitors for Androgen Receptor Activation Surfaces

Androgen receptor activation by polychlorinated biphenyls

The exposure to environmental endocrine disrupting compounds (EDC), as polychlorinated biphenyls (PCBs), widely diffused in the environment may produce epigenetic changes that affect the endocrine system. We found that PCBs activate AR transcriptional activity and that this effect is potentiated by the demethylase Jarid1b, a histone demethylase that catalyzes the removal of trimethylation of ly...

ONCOGENIC ACTIVATION OF THE MET RECEPTOR Tyrosine Kinase PRINCIPAL INVESTIGATOR:

How signalling and biological response to the hepatocyte growth factor (HGF) receptor tyrosine kinase (RTK), Met, are coupled to Met trafficking is largely unknown. The Gab1 scaffold protein modulates Met signals involved in cell dispersal and morphogenesis. We show that Gab1 is indispensable for a form of RTK-induced actin remodelling, called dorsal ruffles, in response to HGF, epidermal and p...

P-231: Androgen Receptor Gene Expression in Azoospermia Men

Background: Androgens are critical steroid hormones in progression of spermatogenesis process and determine the male phenotype that their actions are mediated by the androgen receptor (AR), a member of the nuclear receptor superfamily. In the Androgen receptor, transactivation domain encoded by exon 1, DNA binding domain encoded by exons 2 and 3, hinge region encoded by part of exon 4, and C-te...